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MYP_131869
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Basic Information
PSPHa4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
19 amino acids
C102H165N23O24
Standard
Sequence
FLSLIPKIISAISALINHF
Physicochemical Analysis
2097.54 Da
8.76
0.85
0.59
0.0445
1.50
0.57
0.56
-1.97
174.74
0.1053
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
736.81
-2.53
25.0
26.0
67.0
149.0
4.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019297 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
512 μM
MIC
PMID30774309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30774309/
RECORD: Rec_0074170 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Phylloseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 30774309 PMID30774309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30774309/
RECORD: Rec_0086339 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
2 μM
MIC
PMID30774309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30774309/
RECORD: Rec_0108421 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus (NCTC10788) ( MIC= 2 microM), ( MBC= 2 microM), Escherichia coli (NCTC10418) ( MIC= >512 microM), ( MBC= >512 microM), Candida albicans (NCYC1467) ( MIC= 32 microM), ( MBC= 128 microM), methicillin-resistant Staphylococcus aureus (NCTC12493) ( MIC= 128 microM), ( MBC= 256 microM), Enterococcus faecalis (NCTC12697) ( MIC= 32 microM), ( MBC= 64 microM), Pseudomonas aeruginosa (ATCC 27853) ( MIC= >512 microM), ( MBC= >512 microM), Klebsiella pneumoniae (ATCC 43816) ( MIC= >512 microM), ( MBC= >512 microM)
2 μM
MIC
PMID30774309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30774309/
RECORD: Rec_0124339 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Phylloseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Horse erythrocytes
50 %
Hemolysis
PaperPubMed PMID: 30774309 PMID30774309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30774309/
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