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MYP_131861
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Basic Information
Dermaseptin-B2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
33 amino acids
C142H242N40O42
Standard
Sequence
GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV
Physicochemical Analysis
3181.68 Da
9.70
2.76
2.55
0.0837
0.20
0.68
0.14
7.27
95.15
0.0303
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1318.79
-13.16
46.0
45.0
111.0
224.0
2.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0306941 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Microsporum canis (IP 1194)
10 μg/mL
MIC
PMID8306981;1438301;7842473;8565049 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8306981/
RECORD: Rec_0326837 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperCancerPPD/CancerPPD2 peptide-wise browse result (exact sequence index recovered from visible snippet).
RECORD: Rec_0331066 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Adenoregulin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiprotozoal Interaction with adenosin receptors Guanyl-nucleotide exchange factor activity Inducing behavioral depression
PaperJ.W. Daly et al. / PNAS 89 (1992) 10960-10963. Frog secretions and hunting magic in the upper Amazon: Identification of a peptide that interacts with an adenosine receptor Evidence URLhttps://www.uniprot.org/uniprotkb/P31107/entry
RECORD: Rec_0336492 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
South American frog Phyllomedusa bicolor
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
MDA-MB-231
8.06±0.50 μM
GI50
PMID23028527 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23028527/
RECORD: Rec_0345951 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Dermaseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Cryptococcus neofonnans IP 962-67
15 μg/mL
MIC
PMID8306981 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8306981/
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