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MYP_131861
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Basic Information
Dermaseptin-B2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
33 amino acids
C142H242N40O42
Standard
Sequence
GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV
Physicochemical Analysis
3181.68 Da
9.70
2.76
2.55
0.0837
0.20
0.68
0.14
7.27
95.15
0.0303
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1318.79
-13.16
46.0
45.0
111.0
224.0
2.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0124481 VERIFIED: NO
Provenance & Taxonomy
Giant leaf [Animal]
Dermaseptin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0129967 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Dermaseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Microsporum canis IP 11 94
10 μg/mL
MIC
PMID8306981 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8306981/
RECORD: Rec_0131086 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Dermaseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Escherichia coli IP 76-24
15 μg/mL
MIC
PMID8306981 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8306981/
RECORD: Rec_0135840 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 78.8%, E 0.0%, T 9.1%, C 12.1% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0145591 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
South American frog Phyllomedusa bicolor
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
PC-3
1.24±0.23 μM
GI50
PMID23028527 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23028527/
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