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MYP_131861
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Basic Information
Dermaseptin-B2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
33 amino acids
C142H242N40O42
Standard
Sequence
GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV
Physicochemical Analysis
3181.68 Da
9.70
2.76
2.55
0.0837
0.20
0.68
0.14
7.27
95.15
0.0303
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1318.79
-13.16
46.0
45.0
111.0
224.0
2.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0091180 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Dermaseptin
8393
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
D-amino-acid content reported
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
Candida albicans
15 μg/mL
MIC
PaperMolecular cloning of a cDNA encoding the precursor of adenoregulin from frog skin. Relationships with the vertebrate defensive peptides, dermaseptins. PMID8466537 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8466537/
RECORD: Rec_0113905 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Dermaseptin
8393
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
D-amino-acid content reported
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
N. brasiliensis IP 16-80
30 μg/mL
MIC
PaperMolecular cloning of a cDNA encoding the precursor of adenoregulin from frog skin. Relationships with the vertebrate defensive peptides, dermaseptins. PMID8466537 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8466537/
RECORD: Rec_0117957 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic
A1
RECORD: Rec_0119134 VERIFIED: YES
Provenance & Taxonomy
American frog [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Ade notation
Bio-Activity Profile
Anticancer
PMID23028527 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23028527/
RECORD: Rec_0122313 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Dermaseptin
8393
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
D-amino-acid content reported
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
Cryptococcus neoformans IP 960-67 or IP 962-67
15 μg/mL
MIC
PaperMolecular cloning of a cDNA encoding the precursor of adenoregulin from frog skin. Relationships with the vertebrate defensive peptides, dermaseptins. PMID8466537 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8466537/
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