Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-Influenza virus

Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza

Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV cross

Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV ▸ Anti-HPIV3 cross

Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC179H288N54O59

DescriptionStandard

        ISIELNKAKSDLEESKEWIRRSNQKLDSIGNWHQS
    

Molecular Weight4140.53 Da

Isoelectric Point (pI)6.78

Net Charge (pH 7.0)-0.14

Net Charge (pH 7.4) -0.41

Charge Density (pH 7.0) -0.0041

GRAVY Index-1.20

Hydrophobic Moment 0.66

Boman Index-0.28

Instability Index83.33

Aliphatic Index 80.86

Aromaticity 0.0571

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1901.49

LogP -21.17

H-bond Donors 66.0

H-bond Acceptors 60.0

Rotatable Bonds 147.0

Heavy Atoms 292.0

Ring Count 5.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0252122 VERIFIED: YES

Provenance & Taxonomy

OrganismHuman parainfluenza virus 3 [Virus]

FamilyVirus-derived peptide

Tax ID11216;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor Cytoprotective

TargetHuman parainfluenza virus type 3 (Fusion); HEp2

Activity2 μM

MethodEC50

PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/

RECORD: Rec_0341817 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyRespiratory syncytial virus fusion-inhibitory peptide

Tax ID32630.0

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Bio-Activity Profile

Function

Antiviral Anti-Influenza Anti-RSV Anti-HPIV3 Fusion inhibitor

TargetHuman parainfluenza virus 3

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