Peptide Database

Peptide NameSLAY-screened peptide P5273

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC74H105N21O24S

DescriptionStandard

        DCAHNFSHPVYTNSI
    

Molecular Weight1704.82 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-1.08

Net Charge (pH 7.4) -1.40

Charge Density (pH 7.0) -0.0717

GRAVY Index-0.42

Hydrophobic Moment 0.42

Boman Index0.08

Instability Index-0.35

Aliphatic Index 52.00

Aromaticity 0.1333

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 723.69

LogP -8.94

H-bond Donors 25.0

H-bond Acceptors 26.0

Rotatable Bonds 49.0

Heavy Atoms 120.0

Ring Count 5.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0340169 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/