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MYP_131677
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Basic Information
Centrocin 1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
30 amino acids
C148H225N45O36S
Standard
Sequence
GWFKKTFHKVSHAVKSGIHAGQRGCSALGF
Physicochemical Analysis
3242.71 Da
10.48
5.01
4.63
0.1669
-0.21
0.60
0.08
15.44
55.33
0.1333
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1299.04
-13.24
48.0
45.0
107.0
230.0
8.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0259631 VERIFIED: YES
Provenance & Taxonomy
Strongylocentrotus droebachiensis [other]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
The single Cys residue will link with another short peptide chain DLRGACAAAHAL to form the complete two chain AMP. In addition, the Trp residue is brominated
Bio-Activity Profile
Antimicrobial
L. anguillarum serotype O2
2.5 μM
MIC
PaperCentrocins: Isolation and characterization of novel dimeric antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis
RECORD: Rec_0266003 VERIFIED: NO
Provenance & Taxonomy
Green sea [Animal]; Animalia [Animal]
33208; 33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0347874 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0357480 VERIFIED: YES
Provenance & Taxonomy
Strongylocentrotus droebachiensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0380409 VERIFIED: YES
Provenance & Taxonomy
Strongylocentrotus droebachiensis [Animal]
Centrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperDev Comp Immunol. 2010 Sep;34(9):959-68. | http://www.ncbi.nlm.nih.gov/pubmed/20438753 PMID20438753 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20438753/
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