Peptide Database

Peptide NameSLAY-screened peptide P4168

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC85H145N23O29S

DescriptionStandard

        TRSPTHTLSLCALELLTE
    

Molecular Weight1985.26 Da

Isoelectric Point (pI)5.52

Net Charge (pH 7.0)-1.51

Net Charge (pH 7.4) -1.78

Charge Density (pH 7.0) -0.0841

GRAVY Index0.14

Hydrophobic Moment 0.34

Boman Index0.08

Instability Index64.78

Aliphatic Index 113.89

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 835.79

LogP -9.21

H-bond Donors 31.0

H-bond Acceptors 30.0

Rotatable Bonds 63.0

Heavy Atoms 138.0

Ring Count 2.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0391510 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/