Peptide Database

Peptide NameEsculentin-2-ALa (Amolopin-9a)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length76 amino acids

Chemical FormulaC372H612N100O109S5

DescriptionStandard

        MFTLKKSMLLLFFLGTISLSLCEEERNADEDDGEKEVKRGIFALIKTAAKFVGKNLLKQAGKAGLEHLACKANNQC
    

Molecular Weight8389.77 Da

Isoelectric Point (pI)8.50

Net Charge (pH 7.0)1.57

Net Charge (pH 7.4) 1.23

Charge Density (pH 7.0) 0.0207

GRAVY Index-0.09

Hydrophobic Moment 0.71

Boman Index0.01

Instability Index20.27

Aliphatic Index 95.13

Aromaticity 0.0658

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3411.42

LogP -30.37

H-bond Donors 119.0

H-bond Acceptors 117.0

Rotatable Bonds 299.0

Heavy Atoms 586.0

Ring Count 6.0

Amide Bonds 81.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0025967 VERIFIED: YES

Provenance & Taxonomy

OrganismAmolops loloensis [Animal]

FamilyFrog skin active peptide (FSAP); Esculentin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0033532 VERIFIED: YES

Provenance & Taxonomy

OrganismAmolops loloensis [Animal]

FamilyFrog skin active peptide (FSAP); Esculentin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0116168 VERIFIED: YES

Provenance & Taxonomy

OrganismAmolops loloensis [Animal]

FamilyFrog skin active peptide (FSAP); Esculentin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetCandida albicans

RECORD: Rec_0192191 VERIFIED: YES

Provenance & Taxonomy

OrganismAmolops loloensis [Animal]

FamilyFrog skin active peptide (FSAP); Esculentin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetB. cereus (Gram-positive)

RECORD: Rec_0357639 VERIFIED: YES

Provenance & Taxonomy

OrganismAmolops loloensis [Animal]

FamilyFrog skin active peptide (FSAP); Esculentin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetB. pumilus (Gram-positive)

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