Peptide Database

Peptide NameBrevicidineB

Function Ontology

Antimicrobial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC70H102N18O16

DescriptionStandard

        NFWKKGKWTIGS
    

Molecular Weight1451.67 Da

Isoelectric Point (pI)10.30

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.2298

GRAVY Index-1.00

Hydrophobic Moment 0.39

Boman Index-0.03

Instability Index-30.03

Aliphatic Index 32.50

Aromaticity 0.2500

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 576.61

LogP -3.63

H-bond Donors 21.0

H-bond Acceptors 19.0

Rotatable Bonds 47.0

Heavy Atoms 104.0

Ring Count 5.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0377256 VERIFIED: YES

Provenance & Taxonomy

OrganismBrevibacillus laterosporus [Bacterium]

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermLipidation

C-TermEsterification

Other Modsthree ornithines at positions 4,5, and 7 are represented with K in the sequence

Bio-Activity Profile

Function

Antimicrobial

TargetPseudomonas aeruginosa PAO1

Activity2 μg/mL

MethodMIC

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