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MYP_131587
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Basic Information
Insulin A chain
Anticancer
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Metabolic
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
21 amino acids
C99H155N25O35S4
Standard
Sequence
GIVEQCCTSICSLYQLENYCN
Physicochemical Analysis
2383.70 Da
4.05
-2.28
-2.54
-0.1084
0.21
0.41
0.14
22.54
88.10
0.0952
2980.00
3230.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
993.43
-11.44
37.0
37.0
77.0
163.0
2.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0385286 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Insulin
32630
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Hormone replacement Enzyme replacement
81 mins. SC injection
Evidence URLhttps://patents.google.com/patent/US5866538 PatentUS5866538
RECORD: Rec_0405762 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
insulin family
9823; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
6-11
Bio-Activity Profile
Hormone Insulin family Growth factor signaling
PaperPDB 1M5A structural record; X-ray; 1.20 A; chain A/C; residues 1-21
RECORD: Rec_0411486 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Escherichia coli [Bacterium]
Insulin
9606;562
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Hormone replacement Enzyme replacement
Elimination half life= 42 minutes (SC injection)
Evidence URLhttps://patents.google.com/patent/US6960561 PatentUS6960561
RECORD: Rec_0417315 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Escherichia coli [Bacterium]
Insulin
9606;562
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Hormone replacement
Systemic insulin disposition (apparent terminal half-life) following oral inhalation of 4 to 48 units of human insulin was 120-206 minutes.
Evidence URLhttps://webs.iiitd.edu.in/raghava/thpdb2/display_thppid.php?details=Th1140
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