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MYP_131587
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Basic Information
Insulin A chain
Anticancer
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Metabolic
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
21 amino acids
C99H155N25O35S4
Standard
Sequence
GIVEQCCTSICSLYQLENYCN
Physicochemical Analysis
2383.70 Da
4.05
-2.28
-2.54
-0.1084
0.21
0.41
0.14
22.54
88.10
0.0952
2980.00
3230.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
993.43
-11.44
37.0
37.0
77.0
163.0
2.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0178011 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]; Escherichia coli [Bacterium]
Insulin
9606; 4932; 562
Structure & Mods
single-chain therapeutic peptide/protein [Linear]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Phosphorylation
Bio-Activity Profile
Hormone replacement Enzyme replacement
2-3.4 hours
PaperComparison of insulin aspart vs. regular human insulin with or without insulin detemir concerning adipozytokines and metabolic effects in patients with type 2 diabetes mellitus PMID23512415 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23512415/
RECORD: Rec_0182201 VERIFIED: YES
Provenance & Taxonomy
Macaca fascicularis [Animal]
Insulin
9541
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID5657063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/5657063/
RECORD: Rec_0183796 VERIFIED: NO
Provenance & Taxonomy
Sus scrofa [Animal]
Insulin
9823
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Hormone replacement Enzyme replacement
Evidence URLhttps://webs.iiitd.edu.in/raghava/thpdb2/display_thppid.php?details=Th1212
RECORD: Rec_0184345 VERIFIED: YES
Provenance & Taxonomy
Chlorocebus aethiops [Animal]
Insulin
9534
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID4626369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4626369/
RECORD: Rec_0191915 VERIFIED: YES
Provenance & Taxonomy
Pongo pygmaeus [Animal]
Insulin
9600
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID13552701 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/13552701/
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