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MYP_131587
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Basic Information
Insulin A chain
Anticancer
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Metabolic
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
21 amino acids
C99H155N25O35S4
Standard
Sequence
GIVEQCCTSICSLYQLENYCN
Physicochemical Analysis
2383.70 Da
4.05
-2.28
-2.54
-0.1084
0.21
0.41
0.14
22.54
88.10
0.0952
2980.00
3230.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
993.43
-11.44
37.0
37.0
77.0
163.0
2.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0121254 VERIFIED: YES
Provenance & Taxonomy
Physeter catodon [Animal]
Insulin
9755
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-11
Bio-Activity Profile
Hormone Endocrine Metabolic regulation Physiological regulation
Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Insulin A chain (Physeter macrocephalus): PMID 13552701 PMID13552701 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/13552701/
RECORD: Rec_0123224 VERIFIED: YES
Provenance & Taxonomy
Chlorocebus aethiops [Animal]
Insulin
9534
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-11
Bio-Activity Profile
Hormone Endocrine Metabolic regulation Physiological regulation
Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Insulin A chain (Chlorocebus aethiops): PMID 4626369 PMID4626369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4626369/
RECORD: Rec_0149423 VERIFIED: YES
Provenance & Taxonomy
Macaca fascicularis [Animal]
Insulin
9541
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-11
Bio-Activity Profile
Hormone Endocrine Metabolic regulation Physiological regulation
Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Insulin A chain (Macaca fascicularis): PMID 6184262 PMID6184262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6184262/
RECORD: Rec_0174828 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin
9606
Structure & Mods
single-chain therapeutic peptide/protein [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Hormone replacement Enzyme replacement
On subcutaneous administration = 1 hour
Evidence URLhttps://patents.google.com/patent/CA2151560/en PatentCA2151560
RECORD: Rec_0176154 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]; Escherichia coli [Bacterium]
Insulin
9606;4932;562
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Inter-chain and intra-chain disulfide architecture described for insulin therapeutic
Phosphorylation, Lipidation
Bio-Activity Profile
Anticancer Immunomodulatory Hormone replacement Enzyme replacement
CHO
Systemic insulin disposition (apparent terminal half-life) following oral inhalation of 4 to 48 units of human insulin was 120-206 minutes.
Patent8778403
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