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MYP_131587
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Basic Information
Insulin A chain
Anticancer
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Metabolic
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
21 amino acids
C99H155N25O35S4
Standard
Sequence
GIVEQCCTSICSLYQLENYCN
Physicochemical Analysis
2383.70 Da
4.05
-2.28
-2.54
-0.1084
0.21
0.41
0.14
22.54
88.10
0.0952
2980.00
3230.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
993.43
-11.44
37.0
37.0
77.0
163.0
2.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0056096 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID14426955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14426955/
RECORD: Rec_0081347 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]; Escherichia coli [Bacterium]
Insulin
9606; 4932; 562
Structure & Mods
single-chain therapeutic peptide/protein [Linear]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Phosphorylation, Lipidation
Bio-Activity Profile
Hormone replacement Enzyme replacement
2-3.4 hours
RECORD: Rec_0088090 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]
Insulin
9606;4932
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Hormone replacement Enzyme replacement
5 to 7 hours
Evidence URLhttps://patents.google.com/patent/US6011007 PatentUS6011007
RECORD: Rec_0091219 VERIFIED: YES
Provenance & Taxonomy
Gorilla gorilla gorilla [Animal]
Insulin
9595
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID13373434 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/13373434/
RECORD: Rec_0119704 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
insulin family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
6-11
Bio-Activity Profile
Hormone Insulin family Growth factor signaling
PaperPDB 1TRZ structural record; X-ray; 1.60 A; chain A/C; residues 1-21
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