‹ ›
MYP_131559
← PREVIOUS NEXT → BACK
Basic Information
HR2P-M2
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
36 amino acids
C193H321N43O64S
Standard
Sequence
SLTQINTTLLDLEYEMKKLEEVVKKLEESYIDLKEL
Physicochemical Analysis
4299.93 Da
4.48
-4.52
-4.76
-0.1257
-0.41
0.74
-0.06
18.76
124.44
0.0556
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1775.41
-11.30
60.0
61.0
155.0
301.0
2.0
37.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0249673 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
HR2-derived fusion inhibitor
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012 Q1020H
0.762 μM
IC50
PaperCombining a fusion inhibitory peptide targeting the MERS-CoV S2 protein HR1 domain and a neutralizing antibody specific for the S1 protein receptor-binding domain (RBD) showed potent synergism against pseudotyped MERS-CoV with or without mutations in RBD PMID30621343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30621343/
RECORD: Rec_0254628 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
MERS-CoV PsV
5.598 μM
IC90
PMID30192544;29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0284043 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
RBD-derived peptide
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012 Q522H
0.677 μM
IC50
PaperCombining a fusion inhibitory peptide targeting the MERS-CoV S2 protein HR1 domain and a neutralizing antibody specific for the S1 protein receptor-binding domain (RBD) showed potent synergism against pseudotyped MERS-CoV with or without mutations in RBD PMID30621343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30621343/
RECORD: Rec_0285268 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
RBD-derived peptide
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012
0.574 μM
IC50
PaperCombining a fusion inhibitory peptide targeting the MERS-CoV S2 protein HR1 domain and a neutralizing antibody specific for the S1 protein receptor-binding domain (RBD) showed potent synergism against pseudotyped MERS-CoV with or without mutations in RBD PMID30621343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30621343/
RECORD: Rec_0290008 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
HR2-derived fusion inhibitor
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus
0.15 μM
EC50
PaperDiscovery of hydrocarbon-stapled short α-helical peptides as promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) fusion inhibitors PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
FIRST PREV 1 ... 6 7 8 9 10 ... 12 NEXT LAST
Showing 5 records on this page · Page 8 of 12