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MYP_131559
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Basic Information
HR2P-M2
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
36 amino acids
C193H321N43O64S
Standard
Sequence
SLTQINTTLLDLEYEMKKLEEVVKKLEESYIDLKEL
Physicochemical Analysis
4299.93 Da
4.48
-4.52
-4.76
-0.1257
-0.41
0.74
-0.06
18.76
124.44
0.0556
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1775.41
-11.30
60.0
61.0
155.0
301.0
2.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0084443 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
MERS-CoV-D510G PsV
PMID30192544;29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0087301 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
RBD-derived peptide
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012 D509G
0.912 μM
IC50
PaperCombining a fusion inhibitory peptide targeting the MERS-CoV S2 protein HR1 domain and a neutralizing antibody specific for the S1 protein receptor-binding domain (RBD) showed potent synergism against pseudotyped MERS-CoV with or without mutations in RBD PMID30621343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30621343/
RECORD: Rec_0090463 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
MERS-CoV-Q1020H PsV
2.571 μM
IC90
PMID30192544;29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0091053 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
RBD-derived peptide
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012 Q522H
0.045 μM
IC50
PaperCombining a fusion inhibitory peptide targeting the MERS-CoV S2 protein HR1 domain and a neutralizing antibody specific for the S1 protein receptor-binding domain (RBD) showed potent synergism against pseudotyped MERS-CoV with or without mutations in RBD PMID30621343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30621343/
RECORD: Rec_0098996 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
RBD-derived peptide
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012 D510G
0.679 μM
IC50
PaperCombining a fusion inhibitory peptide targeting the MERS-CoV S2 protein HR1 domain and a neutralizing antibody specific for the S1 protein receptor-binding domain (RBD) showed potent synergism against pseudotyped MERS-CoV with or without mutations in RBD PMID30621343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30621343/
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