Peptide Database

Peptide NameHR2P-M2

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC193H321N43O64S

DescriptionStandard

        SLTQINTTLLDLEYEMKKLEEVVKKLEESYIDLKEL
    

Molecular Weight4299.93 Da

Isoelectric Point (pI)4.48

Net Charge (pH 7.0)-4.52

Net Charge (pH 7.4) -4.76

Charge Density (pH 7.0) -0.1257

GRAVY Index-0.41

Hydrophobic Moment 0.74

Boman Index-0.06

Instability Index18.76

Aliphatic Index 124.44

Aromaticity 0.0556

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1775.41

LogP -11.30

H-bond Donors 60.0

H-bond Acceptors 61.0

Rotatable Bonds 155.0

Heavy Atoms 301.0

Ring Count 2.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0405861 VERIFIED: YES

Provenance & Taxonomy

OrganismMiddle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]

FamilyHR2-derived fusion inhibitor

Tax ID1263720

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetMiddle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012 Q1020R

Activity0.119 μM

MethodIC50

PaperCombining a fusion inhibitory peptide targeting the MERS-CoV S2 protein HR1 domain and a neutralizing antibody specific for the S1 protein receptor-binding domain (RBD) showed potent synergism against pseudotyped MERS-CoV with or without mutations in RBD PMID30621343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30621343/

RECORD: Rec_0417792 VERIFIED: YES

Provenance & Taxonomy

OrganismMiddle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]

FamilyRBD-derived peptide

Tax ID1263720

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetMiddle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012 wild-type

Activity0.069 μM

MethodIC50

PaperCombining a fusion inhibitory peptide targeting the MERS-CoV S2 protein HR1 domain and a neutralizing antibody specific for the S1 protein receptor-binding domain (RBD) showed potent synergism against pseudotyped MERS-CoV with or without mutations in RBD PMID30621343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30621343/

RECORD: Rec_0420250 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetQ1020H-MERS-CoV pseudovirus:inhibition of pseudovirus infection in calu-3 cells

Activity1.25±0.18 μM

MethodEC50

RECORD: Rec_0426382 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHuman lung carcinoma Calu-3

Activity50-60 % Cytotoxicity

MethodCytotoxicity

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