Peptide Database

Peptide NameSLAY-screened peptide P4300

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC94H154N32O30S2

DescriptionStandard

        HSLRSDPEPRPRTTPCICPN
    

Molecular Weight2276.56 Da

Isoelectric Point (pI)8.08

Net Charge (pH 7.0)0.83

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0416

GRAVY Index-1.25

Hydrophobic Moment 0.21

Boman Index-0.36

Instability Index67.37

Aliphatic Index 39.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 985.26

LogP -13.19

H-bond Donors 35.0

H-bond Acceptors 34.0

Rotatable Bonds 65.0

Heavy Atoms 158.0

Ring Count 6.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0288353 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/