Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2569H3990N644O743S18

DescriptionStandard

        MCTKTIPVLWGCFVLWHLCLSSSQTIYPGIKARITQRALDYGVQAGMEIIERMLKENNLPDISGSESLEFLKVDYVNYNFSNIKIRAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIANEVKALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLADPPFSPVPFVLPERSNSMLYIGIAEYFFKSASFAYFTAGAFNVTLSTKEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPMINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISFVNSDIEVLEGFLLISTDLKYETSSKQQPSFHGWEGLNLISGQWRGKSAP
    

Molecular Weight56362.20 Da

Isoelectric Point (pI)5.38

Net Charge (pH 7.0)-10.71

Net Charge (pH 7.4) -11.58

Charge Density (pH 7.0) -0.0211

GRAVY Index0.13

Hydrophobic Moment 0.71

Boman Index0.17

Instability Index39.08

Aliphatic Index 101.14

Aromaticity 0.1045

Extinction Coeff. Reduced 51340.00

Extinction Coeff. Oxidized 51715.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0218700 VERIFIED: NO

Provenance & Taxonomy

OrganismChlorocebus sabaeus [Animal]

FamilyBPI/LBP

Tax ID60711

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria