Peptide Database

Peptide NameR-spondin-3

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length256 amino acids

Chemical FormulaC1209H1981N391O381S26

DescriptionStandard

        QNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKVDCDTCFNKNFCTKCKSGFYLHLGKCLDSCPEGLEANNHTMECVSIVHCEASEWSPWSPCMKKGKTCGFKRGTETRVRDILQHPSAKGNLCPPTSETRTCIVQRKKCSKGERGKKGRERKRKKLNKEERKETSSSSDSKGLESSIETPDQQENKERQQQQKRRARDKQQKSVSVSTVH
    

Molecular Weight28923.75 Da

Isoelectric Point (pI)9.46

Net Charge (pH 7.0)25.09

Net Charge (pH 7.4) 24.18

Charge Density (pH 7.0) 0.0980

GRAVY Index-1.04

Hydrophobic Moment 0.60

Boman Index-0.32

Instability Index59.03

Aliphatic Index 43.75

Aromaticity 0.0508

Extinction Coeff. Reduced 18450.00

Extinction Coeff. Oxidized 19825.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0354853 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID10090

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPredicted N-linked glycosylation of asparagine residue at position 15; predicted disulphide bond foramtion between cysteine residues at positions 127 and 169, 138 and 145, and 178 and 185

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetLGR6 (Human)

Activity1.7 nM

MethodIC50