Peptide Database

Peptide NameMotilin(1–12)ghrelin(8–28)

Function Ontology

Gastrointestinal bioactivity ▸ Gastrointestinal motility

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC181H292N56O48

DescriptionStandard

        FVPIFTYGELQREHQRVQQRKESKKPPAKLQPR
    

Molecular Weight4020.60 Da

Isoelectric Point (pI)10.53

Net Charge (pH 7.0)4.85

Net Charge (pH 7.4) 4.58

Charge Density (pH 7.0) 0.1470

GRAVY Index-1.41

Hydrophobic Moment 0.63

Boman Index-0.40

Instability Index50.19

Aliphatic Index 56.06

Aromaticity 0.0909

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1727.76

LogP -15.70

H-bond Donors 58.0

H-bond Acceptors 54.0

Rotatable Bonds 135.0

Heavy Atoms 285.0

Ring Count 8.0

Amide Bonds 37.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0238898 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyMotilin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Gastrointestinal motility

TargetGPR38 agonist activity

Activity0.01-0.01 μM

MethodEC50

Half-LifeIntravenouly injected in Sprague-Dawley rats, in vivo; 666 s