Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length475 amino acids

Chemical FormulaC2366H3758N594O677S16

DescriptionStandard

        MELVCRLTLAFSLALFVGATNAVNPGFVVRLTQKGLDYARQEGMSVLQQELSKIHLPDFSGSTKKQHIKFKYSFNSMVIRSFQLPTSQISLVPNVGLKLSISGAFIQVDGKWKVHSKILSGKGNFDLKVEGLSISVGLQLGSDASGRPTISPSDCSCHISDVKIHVSGKFSWLVDVFHKSIDNALRKDIEGKICPVVTQSISSKLQPLLQTLPVTAKIDSVAAIDYSLTGPPPVTAQSLDVQLKGEFFNIAHRTPPPFSPPTLSLPADPGLMVYFGVSDYLFNTAGFVYQSAGKIESYITDDMIPKNFSVHLNTSSFGILIPMLSKMYPNMLMKLKISTPSAPFLTIEPGNLTTSPIMEIQAYVILPNSTLAPLFLLNLTTTIMVKVSVNSGRIVGDLELSRIEMELVHSDIGPFSVGVLNTAVNYYISSILLPEVNEILQRGYPLPLLDHIQLTDVIIKPSEHFLLFGANVQYG
    

Molecular Weight51869.76 Da

Isoelectric Point (pI)7.70

Net Charge (pH 7.0)1.45

Net Charge (pH 7.4) 0.52

Charge Density (pH 7.0) 0.0030

GRAVY Index0.22

Hydrophobic Moment 0.78

Boman Index0.19

Instability Index40.88

Aliphatic Index 107.05

Aromaticity 0.0821

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30620.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0151070 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyBPI/LBP

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence