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MYP_131366
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Basic Information
G162-177
Antimicrobial
Antiviral
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
not Standard
16 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
DFHFEVFNFVPXSIXG
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0197399 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
stereochemistry not specified [Other]
Acetylation
Amidation
The 'B' at position 12,15 are S-acetamidomethyl cysteine.
Bio-Activity Profile
Antiviral Anti-RSV Entry inhibition
Respiratory syncytial virus(RSV) | HEp-2 cells
60 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperAntiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein. | Gorman JJ, McKimm-Breschkin JL, Norton RS, Barnham KJ. | J Biol Chem. 2001 Oct 19;276(42):38988-94. | DOI:10.1074/jbc.M106288200 | PMID:11487583 PMID11487583 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11487583/
RECORD: Rec_0401430 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
B: S-acetamidomethyl cysteine
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/