Peptide Database

Peptide NameSLAY-screened peptide P478

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC105H148N24O28S2

DescriptionStandard

        YQSPSHGYGFPLMNPCYILA
    

Molecular Weight2258.57 Da

Isoelectric Point (pI)6.73

Net Charge (pH 7.0)-0.17

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0083

GRAVY Index-0.01

Hydrophobic Moment 0.14

Boman Index0.30

Instability Index63.45

Aliphatic Index 63.50

Aromaticity 0.2000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 805.86

LogP -5.59

H-bond Donors 27.0

H-bond Acceptors 31.0

Rotatable Bonds 63.0

Heavy Atoms 159.0

Ring Count 8.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0096242 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/