Peptide Database

Peptide NameNatriuretic peptide NsNP-a

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC141H234N42O46S3

DescriptionStandard

        SGSEVAKIGDGCFGLPLDRIGSASGMGCRSVPKP
    

Molecular Weight3349.82 Da

Isoelectric Point (pI)7.78

Net Charge (pH 7.0)0.44

Net Charge (pH 7.4) 0.20

Charge Density (pH 7.0) 0.0130

GRAVY Index-0.02

Hydrophobic Moment 0.45

Boman Index0.09

Instability Index32.69

Aliphatic Index 68.82

Aromaticity 0.0294

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1386.14

LogP -18.71

H-bond Donors 50.0

H-bond Acceptors 50.0

Rotatable Bonds 109.0

Heavy Atoms 232.0

Ring Count 4.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0201162 VERIFIED: YES

Provenance & Taxonomy

OrganismNotechis scutatus scutatus [Animal]

FamilyNatriuretic peptide NsNP

Tax ID70142

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Receptor modulation

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour