Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length464 amino acids

Chemical FormulaC2302H3586N580O671S18

DescriptionStandard

        MLSLLILLLNLTNHAFGQNPAIKAILTNKGLQYASHIGADWMQEKIGSMIIPDVRGGVHIGIGTVNYVLDGISVSGCDVPEPSVEFYEGVGLKAVISGLSISFTGNWHTRFGIITDGGSFDLAVFNVDVASVVQIGSDCSGHISISSENCDAKIDEASINFHGGASLIFQPFVTLFHNRIKAIIEERICPVVEEHVTDLERHLAEMQVSFKVNSALVLDVPLTNSPLVDSISLGLDLKGEFYSVQSHTDPPFKAEPFNLPEDNDHMLSLGLSEFTVNSASYAYFSAGLLQAQINDSMVCIPKTSPFRLNTTSFGPLIPQLPKLFPNMLMELQVYARDVPMFSFQADKVTLKFPGAVKAFAIQPNASWTPLFKLNVDSIFSGVIRISEEKLKGLMELSNFTLTLASSEVGIFQVGCKDTPNDWTAEIVTLNYWCLFVAAKLEEGIVLPTMHHIHLVNPALKIQEV
    

Molecular Weight50699.75 Da

Isoelectric Point (pI)5.03

Net Charge (pH 7.0)-19.28

Net Charge (pH 7.4) -20.41

Charge Density (pH 7.0) -0.0416

GRAVY Index0.24

Hydrophobic Moment 0.66

Boman Index0.21

Instability Index32.23

Aliphatic Index 103.97

Aromaticity 0.0884

Extinction Coeff. Reduced 39420.00

Extinction Coeff. Oxidized 39795.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0253279 VERIFIED: NO

Provenance & Taxonomy

OrganismHucho hucho [Bacterium]

FamilyBPI

Tax ID62062

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence