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MYP_130958
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Basic Information
Mram 8
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C132H216N36O40S6
Standard
Sequence
GIPCGESCVFIPCLTSAIGCSCKSKVCYRN
Physicochemical Analysis
3139.73 Da
8.33
1.70
1.40
0.0567
0.55
0.33
0.17
25.08
74.67
0.0667
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1205.35
-14.74
48.0
48.0
99.0
214.0
4.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0115007 VERIFIED: NO
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0189697 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant],Melicytus ramiflorus [Plant],Viola philippica [Plant]
Cyclotide
214053;344147;39648
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic Enzymatic-degradation
Human gastric cancer BGC-823
1.75±0.05 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola philippica | PubMed PMID 19462040 PMID19462040 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19462040/
RECORD: Rec_0221664 VERIFIED: YES
Provenance & Taxonomy
Melicytus ramiflorus [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0306506 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 21723349 PMID21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
RECORD: Rec_0422923 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant],Melicytus ramiflorus [Plant],Viola philippica [Plant]
Cyclotide
214053;344147;39648
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic Enzymatic-degradation
Human skin melanoma MM96L
4.91±0.04 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola philippica | PubMed PMID 19462040 PMID19462040 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19462040/
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