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MYP_130957
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Basic Information
Nigrocin-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
33 amino acids
C144H256N40O44S3
Standard
Sequence
GLLDSIKGMAISAGKGALQNLLKVASCKLDKTC
Physicochemical Analysis
3348.01 Da
9.24
2.74
2.50
0.0830
0.36
0.51
0.13
15.88
115.45
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1366.32
-14.75
49.0
50.0
120.0
231.0
0.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0105564 VERIFIED: YES
Provenance & Taxonomy
Rana nigromaculata [Animal]
Nigrocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
P.mirabilis
PMID11682065 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11682065/
RECORD: Rec_0109903 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Nigrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
100 μg/mL
MIC
PaperStructural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata.
RECORD: Rec_0113818 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Nigrocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PaperPubMed PMID: 11682065 PMID11682065 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11682065/
RECORD: Rec_0131514 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0163182 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Nigrocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Proteus mirabilis
200 μg/mL
MIC
PaperPubMed PMID: 11682065 PMID11682065 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11682065/
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