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MYP_130957
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Basic Information
Nigrocin-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
33 amino acids
C144H256N40O44S3
Standard
Sequence
GLLDSIKGMAISAGKGALQNLLKVASCKLDKTC
Physicochemical Analysis
3348.01 Da
9.24
2.74
2.50
0.0830
0.36
0.51
0.13
15.88
115.45
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1366.32
-14.75
49.0
50.0
120.0
231.0
0.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0035641 VERIFIED: YES
Provenance & Taxonomy
Rana nigromaculata [Animal]
Nigrocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
S.dysenteriae
PMID11682065 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11682065/
RECORD: Rec_0038617 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Nigrocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PaperPubMed PMID: 11682065 PMID11682065 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11682065/
RECORD: Rec_0058156 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Nigrocin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial
PaperL. Wang et al. / FEBS Journal 277 (2010) 1519-1531. Nigrocin-2 peptides from Chinese Odorrana frogs - integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis Evidence URLhttps://www.uniprot.org/uniprotkb/P0C008/entry
RECORD: Rec_0061687 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Nigrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Pseudomonas aeruginosa
75 μg/mL
MIC
PaperStructural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata.
RECORD: Rec_0097112 VERIFIED: YES
Provenance & Taxonomy
Rana nigromaculata [Animal]
Nigrocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
PMID11682065 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11682065/
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