Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2314H3683N587O676S18

DescriptionStandard

        MILSWCLVLVTFTSTTFGTNPGVQVRLTQKGLEYGRQLGITSLQQKLGSVTIPDFSGSQSVSPIGNVKYSLTNINLVNVGLPKSALDLVPGTGVRLSIGDAFMNLHGDWRVKYLYVIKDSGSFDVNVNGLSITTSIAVSSDETGRPAVDVANCAASVASADVKFHGGASWLYNLFSKFIDKALRDALQEQICPLVVKAVADLNPTLRTLNVLAKVDKYAEIEYSMVSSPIVTASSLDLSLKGEFYNIGKHREPPFSPAAFSLPPQTDNMVYIALSAFTPSSAGFVYNKAGVMSLYITDDMVPKESPVRLNTNTFGVFIPQIKKQFPGLMMKLLLKTLDNPTITFQPKNATVEVNGTMTAYAVQPNGTLSPLFVLNMESSVSSDVFVSGLNFAGRVSLNRMKLTLATSYVGLFQVSTLNSIFQTVLKVVVIPVVNVQLAKGYPLPALGKMNLVNPQVQMMKDYMLIGTDVTFTA
    

Molecular Weight51119.69 Da

Isoelectric Point (pI)8.98

Net Charge (pH 7.0)5.74

Net Charge (pH 7.4) 5.24

Charge Density (pH 7.0) 0.0121

GRAVY Index0.24

Hydrophobic Moment 0.84

Boman Index0.18

Instability Index31.42

Aliphatic Index 100.89

Aromaticity 0.0867

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 38975.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0206113 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius furzeri [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria