Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length490 amino acids

Chemical FormulaC2453H3871N611O702S22

DescriptionStandard

        MSPCCCLALLALLPFALATNPGVKVKLTEKGIEYGKQIGMASLQQKLKTMKVPDLSGTERVAPIGKVKYSLTGITIVNLGLPYSALALVPDTGIRLSITNAFISLHGNWKIRYLSFIKDSGSFDLEVNGLTVTDSITIKSDETGRPTVSSVNCVANVGSASIKFHGGASWLYNLFSAYIDKALRSALQKQICPLVADTITDMNPHLKTLNVLAKVDKYAEVEYSMVTSPTISNTSIDFSLKGEFYNIGKHQEPPFSPTPFSLPPQVNNMLYIGMSAFTTNSAGFVYNNAGALSLYITDDMIPPSSPIRLNTRTFGAFIPEIAKRFPSMMMKLLVKTVKEPTIFFEPNNVTVQASGSVTAYAIQPNTTLSPLFVLNMEGSVSARLYVTGVKLAGAVTLNKIEMTLETSYVGQFQVRSLDNIFLMVLKVAVIPKVNGDQIIPFSGVLWWRTEWVEHNTSTLLPIDRLEMLIIYFYCYETCIQLPSLWHTTSF
    

Molecular Weight53859.08 Da

Isoelectric Point (pI)8.64

Net Charge (pH 7.0)4.98

Net Charge (pH 7.4) 4.25

Charge Density (pH 7.0) 0.0102

GRAVY Index0.20

Hydrophobic Moment 0.70

Boman Index0.18

Instability Index29.69

Aliphatic Index 99.65

Aromaticity 0.0959

Extinction Coeff. Reduced 59820.00

Extinction Coeff. Oxidized 60195.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0405075 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus tshawytscha [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence