Peptide Database

Peptide NameSLAY-screened peptide P2708

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H157N31O29S2

DescriptionStandard

        RHNRDVIPYSPAPCLPMYNN
    

Molecular Weight2357.67 Da

Isoelectric Point (pI)8.21

Net Charge (pH 7.0)0.84

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0418

GRAVY Index-0.86

Hydrophobic Moment 0.45

Boman Index-0.14

Instability Index94.32

Aliphatic Index 58.50

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 960.80

LogP -9.43

H-bond Donors 32.0

H-bond Acceptors 33.0

Rotatable Bonds 67.0

Heavy Atoms 165.0

Ring Count 7.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0351432 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/