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MYP_130733
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Basic Information
PIH
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
42 amino acids
C207H340N48O72S2
Standard
Sequence
CGGGGGSLTEINTELLDLEYEMKKLEEVVKKLEESYIDLKEL
Physicochemical Analysis
4717.32 Da
4.32
-6.23
-6.47
-0.1483
-0.40
0.74
0.00
44.81
106.67
0.0476
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1961.29
-15.22
67.0
68.0
170.0
329.0
2.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0124815 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 31099550 PMID31099550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31099550/
RECORD: Rec_0158122 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MERS-COV Fusion inhibition
MERS-CoV | 293T cells; Huh-7 cells
1.171 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperNovel Gold Nanorod-Based HR1 Peptide Inhibitor for Middle East Respiratory Syndrome Coronavirus. | Huang X, Li M, Xu Y, Zhang J, Meng X, An X, Sun L, Guo L, Shan X, Ge J, Chen J, Luo Y, Wu H, Zhang Y, Jiang Q, Ning X. | ACS Appl Mater Interfaces. 2019 Jun 5;11(22):19799-19807. | DOI:10.1021/acsami.9b04240 | PMID:31099550 PMID31099550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31099550/
RECORD: Rec_0163536 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
MERS-CoV:inhibition of cell-cell fusion between 293T cells and Huh-7 cells
1.171 μM
IC50
PaperPubMed PMID: 31099550 PMID31099550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31099550/
RECORD: Rec_0183624 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus [Virus]
Gold nanorod-conjugated fusion inhibitor
1335626
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Gold nanorod conjugation
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus
1.171 μM
IC50
PaperNovel gold nanorod-based HR1 peptide inhibitor for Middle East Respiratory Syndrome Coronavirus PMID31099550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31099550/
RECORD: Rec_0249167 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PIH displayed no significant cytotoxicity to 293T, Huh-7, and L02 cells even at a high concentration of 100 μM
PaperPubMed PMID: 31099550 PMID31099550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31099550/
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