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MYP_130697
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Basic Information
vitri D
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C127H190N36O41S6
Standard
Sequence
GLPVCGETCFTGSCYTPGCSCNWPVCNRN
Physicochemical Analysis
3069.47 Da
5.96
-0.30
-0.59
-0.0103
-0.03
0.23
0.12
44.29
33.45
0.1034
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1217.39
-17.25
47.0
47.0
88.0
210.0
7.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0025059 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 20580652 PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0066816 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial
Human hepatocarcinoma BEL-7402
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining PMID20580652;26399490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0074141 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial
Human breast adenocarcinoma MDA-MB-231
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining PMID20580652;26399490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0229390 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial
Human glioblastoma U251-MG
51.65 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining PMID20580652;26399490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0261213 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
BEL-7402
10 μg/mL
IC50
PaperPubMed PMID: 20580652 PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
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