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MYP_130639
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Basic Information
Leucocin A
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
37 amino acids
C169H246N52O50S2
Standard
Sequence
KYYGNGVHCTKSGCSVNWGEAASAGIHRLANGGNGFW
Physicochemical Analysis
3870.21 Da
8.82
1.91
1.57
0.0517
-0.41
0.55
0.11
-0.46
47.57
0.1351
13980.00
14105.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1644.84
-20.99
60.0
56.0
122.0
273.0
9.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037085 VERIFIED: YES
Provenance & Taxonomy
Leuconostoc mesenteroides [Bacterium]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli TOP10
15.6 OD_ID (dimensionless)
Mex pooled growth-inhibition assay
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0077748 VERIFIED: NO
Provenance & Taxonomy
Leuconostoc mesenteroides [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23936441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23936441/
RECORD: Rec_0129594 VERIFIED: YES
Provenance & Taxonomy
Leuconostoc mesenteroides [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial
Listeria innocua
Qualitative functional evidence
PaperPubMed PMID: 1487737 | PubMed PMID: 7551032 PMID1487737;7551032 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1487737/
RECORD: Rec_0150210 VERIFIED: YES
Provenance & Taxonomy
Leuconostoc mesenteroides [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial
Listeria monocytogenes
Qualitative functional evidence
PaperPubMed PMID: 1487737 | PubMed PMID: 7551032 PMID1487737;7551032 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1487737/
RECORD: Rec_0151245 VERIFIED: YES
Provenance & Taxonomy
Leuconostoc mesenteroides [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
9-14
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Lactobacillus sakei DSM 20017
0.037 μM
MIC
PaperFleury Y, Abdel Dayem M, Montagne JJ, Chaboisseau E, Le Caer JP, Nicolas P, Delfour A. Covalent Structure, Synthesis, and Structure-Function Studies of Mesentericin Y10537, a Defensive Peptide from Gram-Positive Bacteria Leuconostoc mesenteroides. J Biol Chem. 1996;271(24):14421-14429. doi:10.1074/jbc.271.24.14421. PMID:8662868. PMID8662868
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