Peptide Database

Peptide NameBMAP-18P9

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC112H183N33O20

DescriptionStandard

        GRFKRFRKPFKKLFKKIS
    

Molecular Weight2311.86 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)8.75

Net Charge (pH 7.4) 8.54

Charge Density (pH 7.0) 0.4863

GRAVY Index-1.12

Hydrophobic Moment 0.86

Boman Index-0.50

Instability Index-0.42

Aliphatic Index 43.33

Aromaticity 0.2222

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 911.28

LogP -4.60

H-bond Donors 34.0

H-bond Acceptors 29.0

Rotatable Bonds 83.0

Heavy Atoms 165.0

Ring Count 5.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0405734 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1IIIB:inhibition the cytopathic effect of HIV in CEM-SS cells

Activity3.2 μM

MethodEC50

PaperAnti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins. Antimicrob Agents Chemother. 2008 Sep;52(9):3438-3440. doi: 10.1128/AAC.00452-08. PMID: 18591279. PMID18591279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18591279/

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