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MYP_130536
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Basic Information
Neutrophil defensin 3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
33 amino acids
C162H266N58O42S6
Standard
Sequence
VTCFCRRRGCASRERLIGYCRFGNTIYGLCCRR
Physicochemical Analysis
3890.60 Da
9.80
6.68
6.37
0.2023
-0.19
0.49
-0.27
52.17
59.09
0.1212
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1671.26
-19.14
71.0
55.0
128.0
268.0
4.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0135661 VERIFIED: YES
Provenance & Taxonomy
Golden hamster or [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
It contains three disulfide bonds: 3,31; 5,20; 10,30
Bio-Activity Profile
Antimicrobial Antifungal
K. oxytoca
2.6 μg/mL
IC50
PaperIsolation, antimicrobial activities, and primary structures of hamster neutrophil defensins.
RECORD: Rec_0141527 VERIFIED: NO
Provenance & Taxonomy
Mesocricetus auratus [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Defensin Antifungal Fungicide Anti-Gram-positive Non-hemolytic Non-ribosomal
Gram-positive bacteria
Qualitative functional evidence
PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/; https://www.uniprot.org/uniprotkb/P81467/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0151295 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31; 5-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
PaperPubMed PMID: 8890190 PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
RECORD: Rec_0167790 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0186088 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31; 5-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Cryptococcus neoformans
PaperPubMed PMID: 8890190 PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
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