Peptide Database

Peptide NameA5 (IG-19 analogs)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC112H196N34O22

DescriptionStandard

        IGKLFKRIVQRIKKFLRNL
    

Molecular Weight2370.97 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)6.76

Net Charge (pH 7.4) 6.55

Charge Density (pH 7.0) 0.3556

GRAVY Index-0.09

Hydrophobic Moment 1.02

Boman Index-0.21

Instability Index17.48

Aliphatic Index 138.42

Aromaticity 0.1053

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 963.08

LogP -4.38

H-bond Donors 35.0

H-bond Acceptors 29.0

Rotatable Bonds 87.0

Heavy Atoms 168.0

Ring Count 2.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0034745 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetSalmonella typhimurium KCTC 1926

Activity4 μM

MethodMIC

RECORD: Rec_0092721 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

PaperProkaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37. Peptides. 2012 Jun;35(2):239-247. doi: 10.1016/j.peptides.2012.04.004. PMID: 22521196. PMID22521196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22521196/

RECORD: Rec_0109994 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0146320 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli (KCTC 1682)

Activity8 μM

MethodMIC

PaperProkaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37. Peptides. 2012 Jun;35(2):239-247. doi: 10.1016/j.peptides.2012.04.004. PMID: 22521196. PMID22521196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22521196/

RECORD: Rec_0189487 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetBacillus subtilis KCTC 3068

Activity4 μM

MethodMIC

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