Peptide Database

Peptide NameSLAY-screened peptide P4359

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC56H97N25O21

DescriptionStandard

        ARASSPRSRSNNPG
    

Molecular Weight1456.52 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)2.80

Net Charge (pH 7.4) 2.61

Charge Density (pH 7.0) 0.1997

GRAVY Index-1.69

Hydrophobic Moment 0.22

Boman Index-0.56

Instability Index123.51

Aliphatic Index 14.29

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 776.84

LogP -15.11

H-bond Donors 28.0

H-bond Acceptors 24.0

Rotatable Bonds 45.0

Heavy Atoms 102.0

Ring Count 2.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0266326 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/