Peptide Database

Peptide NameInsulin Glargine

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC97H152N24O34S4

DescriptionStandard

        GIVEQCCTSICSLYQLENYCG
    

Molecular Weight2326.64 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-2.28

Net Charge (pH 7.4) -2.54

Charge Density (pH 7.0) -0.1084

GRAVY Index0.36

Hydrophobic Moment 0.41

Boman Index0.20

Instability Index22.54

Aliphatic Index 88.10

Aromaticity 0.0952

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 950.34

LogP -10.69

H-bond Donors 36.0

H-bond Acceptors 36.0

Rotatable Bonds 75.0

Heavy Atoms 159.0

Ring Count 2.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0177908 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Escherichia coli [Bacterium]

FamilyInsulin

Tax ID9606; 562

Structure & Mods

Configsingle-chain therapeutic peptide/protein [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPhosphorylation, Lipidation

Bio-Activity Profile

Function

Hormone replacement Enzyme replacement

Half-LifeNot reported in humans; 30 hours in mammalian reticulocytes.