Peptide Database

Peptide NameSLAY-screened peptide P5588

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC97H163N27O28S

DescriptionStandard

        ACPTDIKDRGTPLLIFLRGT
    

Molecular Weight2187.56 Da

Isoelectric Point (pI)8.27

Net Charge (pH 7.0)0.79

Net Charge (pH 7.4) 0.58

Charge Density (pH 7.0) 0.0394

GRAVY Index0.07

Hydrophobic Moment 0.37

Boman Index0.04

Instability Index25.73

Aliphatic Index 102.50

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 883.75

LogP -7.95

H-bond Donors 32.0

H-bond Acceptors 30.0

Rotatable Bonds 69.0

Heavy Atoms 153.0

Ring Count 3.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0253907 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/