Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length469 amino acids

Chemical FormulaC2385H3769N605O660S14

DescriptionStandard

        DKGEKMLKTWYSFVLCWLSLRLEANPGLKVRITQKGLDYGRRIGMELLKQAVSKETFPSWSGQESFSVVKVNYVISRLRINAVDFPETSASFIPGTGISLSVAHASATISADWKMDAWLLKDQGEITVSISGLFIAIIFKVSRDSKGRLSMLLHNCQLSINSVKVKLNGGSSWIYSFLSGYLEKPIHTKLDKNLCPNIKYKIQMMDAQLRKHNVLNQIDAFAQIDYSLVSSPVVFKSHINLDLKGTVYPVGNHIDPPFVPAPFDLPNQGDSMLYLGVSSYFLKSASLAYYRAGAFNITISEEVSIISIFFLFEIPQIALSYITACPVLLKLLATSPPAVSLNAGRCILQITGWVEVFAVLPNSTTQYIFAGNLTASTRANLTITKQKLIISLLLKRLQFSLVHSALGFSEMSPVENFMSYALRSVVIPVINDKLGKGFPLPNLAHTTLTGPVIKINQGHLVISTDVYYK
    

Molecular Weight51927.00 Da

Isoelectric Point (pI)9.39

Net Charge (pH 7.0)14.51

Net Charge (pH 7.4) 13.67

Charge Density (pH 7.0) 0.0309

GRAVY Index0.22

Hydrophobic Moment 0.72

Boman Index0.17

Instability Index35.22

Aliphatic Index 108.70

Aromaticity 0.1002

Extinction Coeff. Reduced 63830.00

Extinction Coeff. Oxidized 64080.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0043155 VERIFIED: NO

Provenance & Taxonomy

OrganismTyto alba [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria