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MYP_130439
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Basic Information
sMAP-1
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C88H165N23O20
Standard
Sequence
KLALKALKKLKADLKLA
Physicochemical Analysis
1865.39 Da
10.30
4.76
4.54
0.2797
0.18
0.63
-0.06
-30.54
161.18
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
722.34
-2.24
25.0
25.0
71.0
131.0
0.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0177983 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
64 μg/mL
MIC
PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/
RECORD: Rec_0262796 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
256 μg/mL
MIC
PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/
RECORD: Rec_0292801 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
lactam side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Ⓚ (9) and Ⓓ (13) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge
Bio-Activity Profile
Cytotoxic
HeLa cells
2 μM
Cytotoxicity
PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/
RECORD: Rec_0313635 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
lactam side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Ⓚ (9) and Ⓓ (13) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge
Bio-Activity Profile
Hemolytic
human red blood cells
5 μg/mL
Hemolysis
PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/
RECORD: Rec_0321066 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
lactam side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Ⓚ (9) and Ⓓ (13) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis
>256 μg/mL
MIC
PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/
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