Peptide Database

Peptide NamesMAP-1

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC88H165N23O20

DescriptionStandard

        KLALKALKKLKADLKLA
    

Molecular Weight1865.39 Da

Isoelectric Point (pI)10.30

Net Charge (pH 7.0)4.76

Net Charge (pH 7.4) 4.54

Charge Density (pH 7.0) 0.2797

GRAVY Index0.18

Hydrophobic Moment 0.63

Boman Index-0.06

Instability Index-30.54

Aliphatic Index 161.18

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 722.34

LogP -2.24

H-bond Donors 25.0

H-bond Acceptors 25.0

Rotatable Bonds 71.0

Heavy Atoms 131.0

Ring Count 0.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0049676 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsⓀ (9) and Ⓓ (13) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetPseudomonas aeruginosa

Activity>256 μg/mL

MethodMIC

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

RECORD: Rec_0070935 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsⓀ (9) and Ⓓ (13) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity15 μg/mL

MethodHemolysis

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

RECORD: Rec_0100648 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetPseudomonas aeruginosa

Activity256 μg/mL

MethodMIC

RECORD: Rec_0106875 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsⓀ (9) and Ⓓ (13) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus aureus

Activity64 μg/mL

MethodMIC

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

RECORD: Rec_0153080 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsⓀ (9) and Ⓓ (13) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli

Activity256 μg/mL

MethodMIC

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

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