Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2605H4061N651O731S18

DescriptionStandard

        MCTKMVQILWGCFLLWNLYISSAQTIYPGIKARATQRALDYGIQAGMEMIEQMVKERNIPDLKGSESPEFLKIDYMNYKFINIKINAFSLPNTSLAFVPGVGIRALIKHGTASISTDWEIKSPFFQDTGGAKLFLSGVYFTGIVVLARNDFGHPILKLQDCNAQVSHNDISFSGELSVLYNFFAEPMEKPILKNLNKMLCPIITSEVEALNANLSMLEVLRKIDNYTLLDYSLISSPEITENYVDLNLKGVFYPLENLTDPPFSSVPFVLPEHSDSMIYVGISEYFFKSASYAYFTAGAFNVTLTTNKIFNHLIRNSQGLGNMLPRIAELYILSQPFMVQVLAREPPVVNLLPGNFTLDIPASFVILTQSKNSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFRFSFPESIRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSNIEVLEGFLLISTDLKYKTSLKQQPSFHGWEALNLISGQWRVKPAP
    

Molecular Weight56772.20 Da

Isoelectric Point (pI)6.47

Net Charge (pH 7.0)-1.80

Net Charge (pH 7.4) -2.61

Charge Density (pH 7.0) -0.0036

GRAVY Index0.16

Hydrophobic Moment 0.70

Boman Index0.17

Instability Index42.12

Aliphatic Index 104.62

Aromaticity 0.1085

Extinction Coeff. Reduced 52830.00

Extinction Coeff. Oxidized 53080.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0355486 VERIFIED: NO

Provenance & Taxonomy

OrganismLipotes vexillifer [Animal]

FamilyBPI

Tax ID118797

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence