Peptide Database

Peptide NameDermaseptin-PH

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length23 amino acids

Chemical FormulaC114H190N32O33

DescriptionStandard

        ALWKEVLKNAGKAALNEINNLVQ
    

Molecular Weight2536.92 Da

Isoelectric Point (pI)8.54

Net Charge (pH 7.0)0.80

Net Charge (pH 7.4) 0.60

Charge Density (pH 7.0) 0.0347

GRAVY Index-0.10

Hydrophobic Moment 0.66

Boman Index0.07

Instability Index20.85

Aliphatic Index 127.39

Aromaticity 0.0435

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1087.42

LogP -9.07

H-bond Donors 35.0

H-bond Acceptors 34.0

Rotatable Bonds 88.0

Heavy Atoms 179.0

Ring Count 2.0

Amide Bonds 27.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0396221 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa hypochondrialis [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetMCF-7

Activity0.69 μM

MethodIC50

FIRST PREV 1 2 3

Showing 1 records on this page Ã‚Â· Page 3 of 3