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MYP_130311
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Basic Information
Dermaseptin-PH
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
23 amino acids
C114H190N32O33
Standard
Sequence
ALWKEVLKNAGKAALNEINNLVQ
Physicochemical Analysis
2536.92 Da
8.54
0.80
0.60
0.0347
-0.10
0.66
0.07
20.85
127.39
0.0435
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1087.42
-9.07
35.0
34.0
88.0
179.0
2.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0160317 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Horse erythrocytes
1 %
Hemolysis
PaperPubMed PMID: 29064402 PMID29064402 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29064402/
RECORD: Rec_0173491 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 29064402 PMID29064402 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29064402/
RECORD: Rec_0177080 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Anti-Gram-negative
Escherichia coli
16 μM
MIC
RECORD: Rec_0330672 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
U-251MG
2.36 μM
IC50
PaperPubMed PMID: 29064402 PMID29064402 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29064402/
RECORD: Rec_0395177 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
MDA-MB-435S
9.94 μM
IC50
PaperPubMed PMID: 29064402 PMID29064402 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29064402/
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