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MYP_130264
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Basic Information
28v-GeXIVA
Anticancer
Antimicrobial
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Standard
28 amino acids
C139H231N55O41S4
Standard
Sequence
TCRSSGRYCRSPYDRRRRYCRRITDACV
Physicochemical Analysis
3456.93 Da
10.31
6.36
6.10
0.2271
-1.31
0.84
-0.70
158.81
27.86
0.1071
4470.00
4720.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1633.77
-22.03
69.0
52.0
112.0
239.0
4.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076904 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Conotoxin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Anticancer
PaperCloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. PMID26170295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26170295/ PatentCN112010972A
RECORD: Rec_0102727 VERIFIED: YES
Provenance & Taxonomy
Conus generalis [Animal]
Conotoxin
101304
Structure & Mods
disulfide-constrained linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-9; 20-27
Bio-Activity Profile
Anticancer
4T1 triple-negative breast cancer model
PaperαO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis. PMID38921563 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/38921563/ PatentCN112010959A
RECORD: Rec_0374224 VERIFIED: YES
Provenance & Taxonomy
Conus generalis [Animal]
Conotoxin
101304
Structure & Mods
disulfide-constrained linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-9; 20-27
Bio-Activity Profile
Analgesic
α9α10 nicotinic acetylcholine receptor
0.00461 μM
IC50
PaperNovel αO-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment. PMID36145535 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36145535/ PatentCN112010959A
RECORD: Rec_0411953 VERIFIED: YES
Provenance & Taxonomy
Conus generalis [Animal]
Conotoxin
101304
Structure & Mods
disulfide-constrained linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-27; 9-20
Bio-Activity Profile
Analgesic
α9α10 nicotinic acetylcholine receptor
PaperCloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. PMID26170295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26170295/ PatentCN112010959A