Peptide Database

Peptide NameUnnamed

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition ▸ Release inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length26 amino acids

Chemical FormulaC134H244N46O29

DescriptionStandard

        FAVGLRAIKRALKKLRRGVRKVAKDL
    

Molecular Weight2963.66 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)8.76

Net Charge (pH 7.4) 8.55

Charge Density (pH 7.0) 0.3368

GRAVY Index-0.15

Hydrophobic Moment 1.05

Boman Index-0.29

Instability Index39.41

Aliphatic Index 123.85

Aromaticity 0.0385

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1267.72

LogP -9.26

H-bond Donors 48.0

H-bond Acceptors 38.0

Rotatable Bonds 108.0

Heavy Atoms 209.0

Ring Count 1.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0424997 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-FIV Release inhibition

TargetFeline immunodeficiency virus(FIV-Petaluma) | CrFK cells

Activity5.47 μM

MethodIC50

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min

PaperInhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro. | Ma J, Kennedy-Stoskopf S, Jaynes JM, Thurmond LM, Tompkins WA. | J Virol. 2002 Oct;76(19):9952-61. | DOI:10.1128/jvi.76.19.9952-9961.2002 | PMID:12208971 PMID12208971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12208971/

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