Peptide Database

Peptide NameSLAY-screened peptide P4762

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length5 amino acids

Chemical FormulaC27H42N8O8S

DescriptionStandard

        RVFCD
    

Molecular Weight638.74 Da

Isoelectric Point (pI)6.08

Net Charge (pH 7.0)-0.25

Net Charge (pH 7.4) -0.47

Charge Density (pH 7.0) -0.0491

GRAVY Index0.30

Hydrophobic Moment 0.88

Boman Index-0.17

Instability Index46.52

Aliphatic Index 58.00

Aromaticity 0.2000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 278.92

LogP -2.10

H-bond Donors 11.0

H-bond Acceptors 9.0

Rotatable Bonds 19.0

Heavy Atoms 44.0

Ring Count 1.0

Amide Bonds 4.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0245582 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/